Endocrine Abstracts

Thus far, approximately 30 loci influencing body mass index (BMI) and the risk of obesity have been identified. In this study, we aimed to examine the individual and joint associations of 23 BMI-associated loci identified from recent genome-wide association studies in Caucasians with obesity risk in young Chinese. Birth weight reflects prenatal metabolic adaption and has been related to later-life obesity risk. We particularly assessed whether these genetic variants interacted...

Objective: To investigate the influence of vitamin E (VE) and selenium (Se) on apoptosis of human thyrocyte induced by H2O2.Methods: The human thyroid epithelium cells (TEC) from normal para-adenoma tissues of patients with thyroid adenoma resection were cultured. In prevention groups, vitamin E (50 μmol/l), selenium (10–7 mol/l) or serum-free medium was respectively added into thyrocytes of monolayer culture before H...

Objective: Bisphenol A (BPA) exposure may promote obesity, but its effect on bone mineral density (BMD) has not been reported in humans. In the present study, we aimed to examine the complex interplay between BPA exposure, fat mass, fat-free mass, serum estradiol, leptin, osteocalcin levels and BMDs in a group of premenopausal women.Methods: A total of 246 Chinese premenopausal women aged 20 years and older with regular menstrual cycles were investigated...